The old center around the Grand-Place and Brussels-Central for first-timers on foot; Sainte-Catherine and Dansaert for seafood and bars; the Sablon for an upmarket feel near the museums; the European Quarter for parks and EU sights.
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Walkable to the Grand-Place, the cathedral and the station for day trips, though the lanes around the square are crowded by day.
Hotels in Old center (Grand-Place and Brussels-Central)Seafood restaurants, fashion shops and bars a few minutes from the Grand-Place, so evenings can be lively and loud.
Hotels in Sainte-Catherine and DansaertAn upmarket square of chocolatiers and antique dealers near Place Royale and the museums, halfway up the hill from the lower town.
Hotels in SablonClose to Leopold Park, the Parlamentarium and the Cinquantenaire, but a metro ride from the old center.
Hotels in European QuarterStay in the old center near Brussels-Central: the first day is on foot, and trains to Antwerp and the airport leave from there.
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