The Centro Storico for first-timers who want to walk everywhere, Monti for a local feel near the Colosseum, Trastevere for evenings out, and Prati for a calmer base by the Vatican.
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Between the Pantheon and Piazza Navona: most sights on foot, the classic first-time base.
Hotels in Centro StoricoCobbled lanes full of restaurants and evening life across the river. Can be loud at night.
Hotels in TrastevereStay in the Centro Storico or Monti: most of each day is on foot, and the Vatican, the Borghese Gallery and Testaccio are short rides away.
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