San Marco for the main sights, Cannaregio for a local feel and value, Dorsoduro for museums and quiet canals. Staying on the islands beats Mestre on the mainland.
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Steps from St. Mark's Square and the Rialto. Pricier, and crowded by day.
Hotels in San MarcoWhere many Venetians live: canalside bars, the old Jewish Ghetto and better value.
Hotels in CannaregioMuseums, the Zattere waterfront and quiet canals, across the Accademia Bridge.
Hotels in DorsoduroCalm streets east of St. Mark's, with the Biennale gardens at the far end.
Hotels in CastelloStay in Cannaregio or near the Rialto: day 1 is on foot, and the vaporetto to the islands leaves from Fondamente Nove.
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