Sol and the center for first-timers, Las Letras for the museums and tapas, Malasaña for a younger crowd, Salamanca for an upscale, quieter base.
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Between Puerta del Sol and the Plaza Mayor: everything on foot.
Hotels in Sol and CentroLiterary streets full of tapas bars, a short walk from the Prado.
Hotels in Barrio de las LetrasStay near Sol or in the Barrio de las Letras: days 1 and 2 are on foot, and Atocha station for Toledo is close.
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