Union Square for first-timers and transit; Fisherman's Wharf for families and the Alcatraz ferry; North Beach for cafés and evenings out; Nob Hill for classic hotels on the cable car lines.
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Central, with cable cars and BART close by; check the exact block, as streets toward the Tenderloin feel rough at night.
Hotels in Union SquareEasy for the Alcatraz ferry and the bay, but touristy and quiet after dinner.
Hotels in Fisherman's WharfCafés, Italian restaurants and Chinatown next door, with steep walks to some hotels.
Hotels in North BeachGrand old hotels on the cable car lines and city views, but every walk home is uphill.
Hotels in Nob HillStay near Union Square: the cable cars, BART and buses this plan uses all start close by.
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